Project Categories In vivo model

Safety Pharmacology In Vivo Models

| Pharmacology Discovery Services (Eurofins Discovery Partner Lab) 공식 대리점

INTRODUCTION

Pharmacology Discovery Services는 30년 이상의 in vivo safety and early toxicity testing 경험을 보유하고 있으며, In vivo safety service는 Eurofins Discovery의 in vitro toxicology service와 함께 후보약물에 대한 포괄적인 risk profile을 제공합니다. 또한 중추신경계, 심혈관, 호흡기, 신장, 대사 및 위장 기능에서 확인되는 약물의 부작용을 평가할 수 있는 broad panel을 사용하여 Toxicokinetic (TK) profile을 구축하실 수 있습니다.

MODEL LIST

In Vivo Safety Models
Model Name	Item Number	Species
Cardiovascular, QTc Interval	516350	Guinea Pig
Gastrointestinal Motility	537920	Mouse
Gastrointestinal Motility	537940	Rat
Locomotor Activity	563000	Mouse
Locomotor Activity	563020	Rat
Maximum Tolerated Dose (MTD), Autonomic Signs	560000	Mouse
Maximum Tolerated Dose (MTD), Autonomic Signs	561600	Rat
Modified Irwin Screen	509500	Mouse
Modified Irwin Screen	509600	Rat
Respiration, Rate, Tidal Volume, Minute Volume and Blood Gases	576660	Rat
Rota-Rod	562010	Mouse
Rota-Rod	562600	Rat

REFERENCES

Optimization of Substrate-Analogue Furin Inhibitors. Ivanova T et al., ChemMedChem. 2017 Dec 7;12(23):1953-1968.

서비스 절차

서비스 문의

이름

이메일 주소

소속

연락처

관심분야 (중복선택가능) 관심분야 (중복선택가능) Kinase GPCR BioMAP OncoPanel Safety 서비스 PROTAC 서비스 SPR 서비스 T 세포 면역 반응 서비스(COVID-19) Cardiac Safety 서비스 In vivo model 기타

제목

내용- 화합물개수

내용-타깃개수

내용-농도개수

내용-기타 문의사항에 대해 자유롭게 기술해주세요.

개인정보 취급 방침 동의 개인정보 취급 방침 동의 동의합니다.

DMPK In Vivo Models

| Pharmacology Discovery Services (Eurofins Discovery Partner Lab) 공식 대리점

INTRODUCTION

초기 신약개발 단계에서 Pharmacokinetic (PK) 및 blood-brain barrier (BBB) 연구는 후보약물의 효능 및 독성을 평가하기 위해 필수적으로 수행되어야 하는 연구로서, PDS는 오랜 경험과 기술력을 바탕으로 약물개발 초기 단계의 PK, Oral bioavailability, BBB 데이터를 제공합니다.

후보 약물의 물리화학적 특성을 이해하여 약물의 투여량 및 샘플 수집 계획을 수립
약물 투여를 위한 다양한 방법 (IV, PO, IP, IM, SC, IN 및 ICV, Short- 혹은 long-term continuous infusion)을 적용하여 혈액 및 조직 샘플 수집
Standard method 혹은 custom bioanalytical method를 사용하여 concentration/time curve를도출함으로써 후보 약물에 대한 complete pharmacokinetic profile을 제공

MODEL LIST

In Vivo DMPK Models
Model Name	Item Number	Species
Pharmacokinetics (PK) Study, BBB, In-life, Mouse	515570	Mouse
Pharmacokinetics (PK) Study, BBB, In-life and Bioanalysis, Mouse	515580	Mouse
Pharmacokinetics (PK) Study, BBB, In-life, Rat	515520	Rat
Pharmacokinetics (PK) Study, BBB, In-life and Bioanalysis, Rat	515530	Rat
Pharmacokinetics (PK) Study, Plasma, In-life, Mouse	515550	Mouse
Pharmacokinetics (PK) Study, Plasma, In-life and Bioanalysis, Mouse	515555	Mouse
Pharmacokinetics (PK) Study, Plasma, In-life, Rat	515500	Rat
Pharmacokinetics (PK) Study, Plasma, In-life and Bioanalysis, Rat	515510	Rat

REFERENCES

Vitamin E Phosphate Nucleoside Prodrugs: A Platform for Intracellular Delivery of Monophosphorylated Nucleosides.Diafuku R et al., Pharmaceuticals (Basel). 2018 Feb 6;11(1).
5-aza-2′,2′-Difluoro Deoxycytidine (NUC013): A Novel Nucleoside DNA Methyl Transferase Inhibitor and Ribonucleotide Reductase Inhibitor for the Treatment of Cancer.Diafuku R et al., Pharmaceuticals (Basel). 2017 Jul 20;10(3).
BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases.Papathanassiu AE et al., Nat Commun. 2017 Jul 12;8:16040.

서비스 절차

서비스 문의

이름

이메일 주소

소속

연락처

제목

내용- 화합물개수

내용-타깃개수

내용-농도개수

내용-기타 문의사항에 대해 자유롭게 기술해주세요.

개인정보 취급 방침 동의 개인정보 취급 방침 동의 동의합니다.

Antimicrobial In Vivo Models

| Pharmacology Discovery Services (Eurofins Discovery Partner Lab) 공식 대리점

INTRODUCTION

Eurofins Discovery의 Pharmacology Discovery Services는 BSL-2 (Biosafety Level 2) 시설에서 새로운 Microbial의 발견 및 개발을 위한 in vitro/in vivo service를 지원합니다.

Small molecules, drug combinations, biologics, RNAi, liposomal formulations, nanoparticles, vaccines 모두 사용 가능
High-quality, Reproducible data
Dose-dependent manner
Approved benchmark positive control
Custom Model Development

MODEL LIST

Aspergillus fumigatus In vivo Models
Model Name	Item Number	Species
Aspergillus fumigatus (ATCC 13073), Lung Infection Model, LD90-100	609110	Mouse
Aspergillus fumigatus (ATCC 13073), Systemic (IV) Infection, LD90-100	609100	Mouse

Candida albicans In vivo Models
Model Name	Item Number	Species
Candida albicans (ATCC 10231), Systemic (IV) Infection, LD90-100	609010	Mouse
Candida albicans (ATCC 44858), Systemic (IV) Infection, LD90-100	609020	Mouse
Candida albicans (ATCC 44858), Vulvovaginal Candidiasis	609050	Rat
Candida albicans (R303), Systemic (IV) Infection, Kidney, CFU/g	609035	Mouse
Candida albicans, Azole resistant (R357), Systemic Infection, Kidney, CFU/g	609040	Mouse
Candida albicans, Azole resistant (R357),Vulvovaginal Infection	609060	Rat

Acinetobacter baumannii In vivo Models
Model Name	Item Number	Species
Acinetobacter baumannii (ATCC 17978), Lung Infection Model, CFU/g	608800	Mouse
Acinetobacter baumannii (ATCC 17978), Thigh Infection Model, CFU/g	608830	Mouse
Acinetobacter baumannii ADC-25 OXA-23 OXA-66 (CDC & FDA AR-BANK#0275), Thigh Infection Model, CFU/g	608833	Mouse
Acinetobacter baumannii ADC-25 OXA-23 OXA-66 (CDC & FDA AR-BANK#0282), Lung Infection Model	608820	Mouse
Acinetobacter baumannii ADC-25 OXA-23 OXA-66 (CDC & FDA AR-BANK#0282), Thigh Infection Model	608840	Mouse
Acinetobacter baumannii ADC-25 OXA-66 (CDC & FDA AR-BANK#0280), Peritonitis	608855	Mouse
Acinetobacter baumannii ADC-25 OXA-66 (CDC & FDA AR-BANK#0280), Thigh Infection Model, CFU/g	608835	Mouse
Acinetobacter baumannii NDM-1 (CDC & FDA AR-BANK#0088), Lung Infection Model, CFU/g	608802	Mouse
Acinetobacter baumannii NDM-1 (CDC & FDA AR-BANK#0088), Thigh Infection Model, CFU/g	608832	Mouse
Acinetobacter baumannii OXA-23 OXA-69 (CDC & FDA AR-BANK#0313), Lung Infection Model, CFU/g	608806	Mouse
Acinetobacter baumannii OXA-23 OXA-69 (CDC & FDA AR-BANK#0313), Thigh Infection Model, CFU/g	608836	Mouse
Acinetobacter baumannii OXA-24 OXA-65 (CDC & FDA AR-BANK#0277), Thigh Infection Model, CFU/g	608834	Mouse

Escherichia coli In vivo Models
Model Name	Item Number	Species
Escherichia coli (ATCC 25922), Peritonitis, LD90-100	608310	Mouse
Escherichia coli (ATCC 25922),Thigh Infection Model, CFU/g	608330	Mouse
Escherichia coli (ATCC 700336), Urinary Tract Infection Model, 7 day	608380	Mouse
Escherichia coli KPC-3 (CDC & FDA AR-BANK#0114), Thigh Infection Model, CFU/g	608343	Mouse
Escherichia coli MCR-1 ESBL (CDC & FDA AR-BANK#0349), Thigh Infection Model, CFU/g	608335	Mouse
Escherichia coli NDM-1 (CDC & FDA AR-BANK#0048),Thigh Infection Model, CFU/g	608338	Mouse
Escherichia coli NDM-1 (CDC & FDA AR-BANK#0055),Thigh Infection Model, CFU/g	608340	Mouse
Escherichia coli NDM-1 (CDC & FDA AR-BANK#0055), UTI Model, CFU	608381	Mouse
Escherichia coli UPEC (ATCC 700336),Thigh Infection Model, CFU/g	608332	Mouse

Klebsiella pneumoniae In vivo Models
Model Name	Item Number	Species
Klebsiella pneumoniae (ATCC 10031), Peritonitis, LD90-100	608510	Mouse
Klebsiella pneumoniae (ATCC 43816), Bacteremia, LD90-100	608541	Mouse
Klebsiella pneumoniae (ATCC 43816), IC Lung Infection Model	608560	Mouse
Klebsiella pneumoniae (ATCC 43816), Lung Infection Model, CFU/g	608550	Mouse
Klebsiella pneumoniae (ATCC 43816), Peritonitis, LD90-100	608540	Mouse
Klebsiella pneumoniae (ATCC 43816), Thigh Infection Model, CFU/g	608570	Mouse
Klebsiella pneumoniae (ATCC 43816), Thigh Infection Model, CFU/g	608575	Rat
Klebsiella pneumoniae KPC-2 (BAA-1705), Lung Infection Model, CFU/g	608572	Mouse
Klebsiella pneumoniae KPC-2 (BAA-1705), Thigh Infection Model, CFU/g	608571	Mouse
Klebsiella pneumoniae KPC-2 (BAA-1705), Peritonitis, LD90-100	608530	Mouse
Klebsiella pneumoniae KPC-2 (CDC & FDA AR-BANK#0098), Thigh Infection Model, CFU/g	608580	Mouse
Klebsiella pneumoniae KPC-3 (CDC & FDA AR-BANK#0097), Thigh Infection Model, CFU/g	608579	Mouse
Klebsiella pneumoniae NDM-1 (CDC & FDA AR-BANK#0041), Thigh Infection Model, CFU/g	608577	Mouse
Klebsiella pneumoniae NDM-1 (NCTC-13443), Thigh Infection Model, CFU/g	608573	Mouse
Klebsiella pneumoniae NDM-1 (NCTC-13443), Lung Infection Model, CFU/g	608574	Mouse
Klebsiella pneumoniae NDM-7 (CDC & FDA AR-BANK#0138), Thigh Infection Model, CFU/g	608581	Mouse
Klebsiella pneumoniae OXA-48 (CDC & FDA AR-BANK#0160), Lung Infection Model, CFU/g	608593	Mouse
Klebsiella pneumoniae OXA-48 (CDC & FDA AR-BANK#0160), Thigh Infection Model, CFU/g	608583	Mouse
Klebsiella pneumoniae SHV-12 (CDC & FDA AR-BANK#0087), Thigh Infection Model, CFU/g	608578	Mouse
Klebsiella pneumoniae VIM-1 (CDC & FDA AR-BANK#0135), Thigh Infection Model, CFU/g	608582	Mouse

Neisseria gonorrhoeae In vivo Model
Model Name	Item Number	Species
Neisseria gonorrhoeae (FA1090 ATCC 700825), Vaginal Infection Model	608600	Mouse

Pseudomonas aeruginosa In vivo Models
Model Name	Item Number	Species
Pseudomonas aeruginosa (ATCC 15692), Ocular Infection Model, CFU/g	608690	Mouse
Pseudomonas aeruginosa (ATCC 27853), Lung Infection Model, CFU/g	608640	Mouse
Pseudomonas aeruginosa (ATCC 27853), Peritonitis, LD90-100	608620	Mouse
Pseudomonas aeruginosa (ATCC 27853), Thigh Infection Model, CFU/g	608650	Mouse
Pseudomonas aeruginosa (ATCC 9027), Peritonitis, LD90-100	608610	Mouse
Pseudomonas aeruginosa Carbapenem Resistant (CDC & FDA AR-BANK#0094), Lung Infection Model, CFU/g	608643	Mouse
Pseudomonas aeruginosa Carbapenem Resistant (CDC & FDA AR-BANK#0094), Thigh Infection Model, CFU/g	608653	Mouse
Pseudomonas aeruginosa Carbapenem Resistant (CDC & FDA AR-BANK#0246), 120 h Lung Infection Model	608638	Mouse
Pseudomonas aeruginosa Carbapenem Resistant (CDC & FDA AR-BANK#0246), Bacteremia, LD 90-100	608684	Mouse
Pseudomonas aeruginosa Carbapenem Resistant (CDC & FDA AR-BANK#0246), IC Thigh Infection Model	608674	Mouse
Pseudomonas aeruginosa Carbapenem Resistant (CDC & FDA AR-BANK#0264), Lung Infection Model, CFU/g	608649	Mouse
Pseudomonas aeruginosa Carbapenem Resistant (CDC & FDA AR-BANK#0264), Thigh Infection Model, CFU/g	608659	Mouse
Pseudomonas aeruginosa Carbapenem Resistant (CDC & FDA AR-BANK#0266), 120 h Lung Infection Model	608639	Mouse
Pseudomonas aeruginosa Carbapenem Resistant (CDC & FDA AR-BANK#0266), Bacteremia, LD 90-100	608686	Mouse
Pseudomonas aeruginosa Carbepenem Resistant (LES 431), Lung Infection Model, CFU/g	608645	Mouse
Pseudomonas aeruginosa Carbepenem Resistant (LES 431), Peritonitis, LD90-100	608630	Mouse
Pseudomonas aeruginosa Carbepenem Resistant (LES 431), Thigh Infection Model, CFU/g	608655	Mouse
Pseudomonas aeruginosa IMP-1 (CDC & FDA AR-BANK#0103), Lung Infection Model, CFU/g	608644	Mouse
Pseudomonas aeruginosa IMP-1 (CDC & FDA AR-BANK#0103), Thigh Infection Model, CFU/g	608654	Mouse
Pseudomonas aeruginosa OXA-2 OXA-50 (CDC & FDA AR-BANK#0105), Lung Infection Model, CFU/g	608646	Mouse
Pseudomonas aeruginosa OXA-2 OXA-50 (CDC & FDA AR-BANK#0105), Thigh Infection Model, CFU/g	608656	Mouse
Pseudomonas aeruginosa SPM-1 (CDC & FDA AR-BANK#0064), Lung Infection Model, CFU/g	608642	Mouse
Pseudomonas aeruginosa SPM-1 (CDC & FDA AR-BANK#0064), Thigh Infection Model, CFU/g	608652	Mouse
Pseudomonas aeruginosa VIM-2 (CDC & FDA AR-BANK#0108), Lung Infection Model, CFU/g	608647	Mouse
Pseudomonas aeruginosa VIM-2 (CDC & FDA AR-BANK#0108), Thigh Infection Model, CFU/g	608657	Mouse
Pseudomonas aeruginosa VIM-4 (CDC & FDA AR-BANK#0054), Lung Infection Model, CFU/g	608641	Mouse
Pseudomonas aeruginosa VIM-4 (CDC & FDA AR-BANK#0054), Thigh Infection Model, CFU/g	608651	Mouse

Clostridium difficile Colitis In vivo Model
Model Name	Item Number	Species
Clostridium difficile ribotype 027 (BAA-1805)	608910	Hamster

Enterococcus faecalis In vivo Models
Model Name	Item Number	Species
Enterococcus faecalis (ATCC 29212), Peritonitis, LD90-100	608220	Mouse
Enterococcus faecalis VRE (ATCC 51575), Peritonitis, LD90-100	608250	Mouse
Enterococcus faecalis VRE (ATCC 51575), Systemic (IV), Kidney CFU/g	608270	Mouse

Staphylococcus aureus In vivo Models
Model Name	Item Number	Species
Staphylococcus aureus (ATCC 29213), Thigh Infection Model, CFU/g	608105	Mouse
Staphylococcus aureus (Smith, ATCC 19636), Peritonitis, LD90-100	608010	Mouse
Staphylococcus aureus (Smith, ATCC 19636), Thigh Infection Model CFU/g	608050	Mouse
Staphylococcus aureus (Smith, ATCC 19636),Dermal Infection	608070	Mouse
Staphylococcus aureus MRSA (ATCC 33591), Lung Infection Model, CFU/g	608125	Mouse
Staphylococcus aureus MRSA (ATCC 33591), Peritonitis, LD90-100	608110	Mouse
Staphylococcus aureus MRSA (ATCC 33591), Thigh Infection Model, CFU/g	608130	Mouse
Staphylococcus aureus MRSA (ATCC 33592), Peritonitis, LD90-100	608140	Mouse
Staphylococcus aureus USA300 MRSA (BAA-1556), Dermal Infection	608207	Mouse
Staphylococcus aureus USA300 MRSA (BAA-1556), Lung Infection	608209	Mouse
Staphylococcus aureus USA300 MRSA (BAA-1556), Peritonitis, LD90-100	608206	Mouse
Staphylococcus aureus USA300 MRSA (BAA-1556), Thigh Infection CFU/g	608208	Mouse
Staphylococcus aureus USA300 MRSA (BAA-1717), Dermal Infection	608190	Mouse
Staphylococcus aureus USA300 MRSA (BAA-1717), Disseminated Infection, LD90-100	608188	Mouse
Staphylococcus aureus USA300 MRSA (BAA-1717), Wound Infection, CFU/g	608200	Mouse
Staphylococcus aureus VRSA (VRS-2), Thigh Infection Model, CFU/g	608180	Mouse

Staphylococcus epidermidis In vivo Model
Model Name	Item Number	Species
Staphylococcus epidermidis (ATCC 12228), Peritonitis, LD90-100	608150	Mouse

Streptococcus pneumoniae In vivo Models
Model Name	Item Number	Species
Streptococcus pneumoniae (ATCC 6301), Lung Infection Model, LD90-100	608100	Mouse
Streptococcus pneumoniae (ATCC 6303), Lung Infection Model, CFU/g	608095	Mouse
Streptococcus pneumoniae (ATCC 6301), Peritonitis, LD90-100	608080	Mouse

Streptococcus pyogenes In vivo Model
Model Name	Item Number	Species
Streptococcus pyogenes (ATCC 14289), Peritonitis, LD90-100	608700	Mouse

Septic Shock In vivo Model
Model Name	Item Number	Species
Septic Shock, Cecal Ligation and Puncture	576680	Mouse
Septic Shock, Lipopolysaccharide	576700	Mouse
Septic Shock, Lipopolysaccharide (without galactosamine)	576710	Mouse
Septic Shock, Lipopolysaccharide	576750	Rat

REFERENCES

Efficacy of Rezafungin in Prophylactic Mouse Models of Invasive Candidiasis, Aspergillosis, and Pneumocystis Pneumonia.Miesel L et al., Antimicrob Agents and Chemother. 2021 Feb 17;65(3):e01992-20.
A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance.Martin James K et al., Cell. 2020 May 22;S0092-8674(20)30567-5. doi: 10.1016/j.cell.2020.05.005. Online ahead of print.
Discovery of Cephalosporin-3′-Diazeniumdiolates That Show Dual Antibacterial and Antibiofilm Effects Against Pseudomonas aeruginosa Clinical Cystic Fibrosis Isolates and Efficacy in a Murine Respiratory Infection Model.Rineh Ardeshir et al., ACS Infect Dis. 2020 Jun 12;6(6):1460-1479. doi: 10.1021/acsinfecdis.0c00070. Epub 2020 May 5.
C1-CBP-vancomycin: Impact of a Vancomycin C-Terminus Trimethylammonium Cation on Pharmacological Properties and Insights Into Its Newly Introduced Mechanism of Action.Wu Zhi-Chen et al., J Org Chem. 2020 Feb 7;85(3):1365-1375. doi: 10.1021/acs.joc.9b02314. Epub 2019 Oct 31.
Rezafungin treatment in mouse models of invasive candidiasis and aspergillosis: Insights on the PK/PD pharmacometrics of rezafungin efficacy.Miesel L et al., Pharmacol Res Perspect. 2019 Nov 20;7.
Rapid evolution of reduced susceptibility against a balanced dual-targeting antibiotic through stepping-stone mutations.Szili P et al., Antimicrob Agents Chemother. 2019 June 24. Epub ahead of print.
Antibiotic usage promotes the evolution of resistance against gepotidacin, a novel multi-targeting drug.Preprint, 2018 Dec.
Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining.Li XY et al., Nat Commun. 2018 Aug 16;9(1):3273.
Cysteamine, an Endogenous Aminothiol, and Cystamine, the Disulfide Product of Oxidation, Increase Pseudomonas aeruginosa Sensitivity to Reactive Oxygen and Nitrogen Species and Potentiate Therapeutic Antibiotics against Bacterial Infection.Fraser-Pitt DJ et al., Infect Immun. 2018 May 22;86(6).
Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria.Blaskovich MAT et al., Nat Commun. 2018 Jan 2;9(1):22.
The rumen microbiome: an underexplored resource for novel antimicrobial discovery.Oyama LB et al., NPJ Biofilms Microbiomes. 2017 Dec 1;3:33.
Pharmacological Basis of CD101 Efficacy: Exposure Shape Matters. Lakota EA et al., Antimicrob Agents Chemother. 2017 Oct 24;61(11).
Efficacy of a Novel Tricyclic Topoisomerase Inhibitor in a Murine Model of Neisseria gonorrhoeae Infection.Savage VJ et al., Antimicrob Agents Chemother. 2016 Aug 22;60(9):5592-4.
Antibacterial activity of the novel semisynthetic lantibiotic NVB333 in vitro and in experimental infection models.Boakes S et al., J Antibiot (Tokyo). 2016 Dec;69(12):850-857.
Preclinical development of Ramizol, an antibiotic belonging to a new class, for the treatment of Clostridium difficile colitis.Rao S et al., J Antibiot (Tokyo). 2016 Dec;69(12):879-884.

서비스 절차

서비스 문의

이름

이메일 주소

소속

연락처

제목

내용- 화합물개수

내용-타깃개수

내용-농도개수

내용-기타 문의사항에 대해 자유롭게 기술해주세요.

개인정보 취급 방침 동의 개인정보 취급 방침 동의 동의합니다.

Gastrointestinal and Renal In Vivo Models

| Pharmacology Discovery Services (Eurofins Discovery Partner Lab) 공식 대리점

INTRODUCTION

Eurofins Discovery의 Pharmacology Discovery Services는 30년 이상의 in vivo testing 경험을 바탕으로 Gastrointestinal (GI) disease에 대한 후보 약물의 Efficacy 및 side-effect profiling 연구를 위한 in vivo model을 제공합니다. 후보 약물의 GI mobility, GI safety, colonic function에 대한 영향뿐만 아니라 GI-관련 질병에 대한 효능을 테스트하기 위해서도 사용 가능한 in vivo model입니다

High-quality, Reproducible data
Dose-dependent manner
Approved benchmark positive control
Custom Model Development

MODEL LIST

Gastrointestinal In Vivo Models
Model Name	Item Number	Species
Gastric Acidity, Basal	533000	Rat
Gastric Acidity, Pentagastrin	534000	Rat
Gastric Acidity, Pylorus Ligation	534100	Rat
Gastric Emptying, Test Meal	534550	Rat
Gastric Irritation	535020	Rat
Gastric Ulcers, Aspirin-Induced	535900	Rat
Gastric Ulcers, Ethanol-Induced	536000	Rat
Gastrointestinal Motility	537920	Mouse
Gastrointestinal Motility	537940	Rat
Gastrointestinal Motility, 5-HTP Induced Diarrhea	538200	Mouse
Gastrointestinal Motility, Colonic Propulsion, Clonidine	538100	Mouse
Gastrointestinal Motility, Colonic Propulsion, Loperamide	538110	Mouse
Gastrointestinal Motility, Colonic Propulsion, Morphine	538120	Mouse

Renal In Vivo Models
Model Name	Item Number	Species
Renal Function	576000	Rat
Renal, Acute Renal Failure, Ischemia/Reperfusion	575000	Rat
Renal, Chronic Failure, Remnant Kidney	575500	Rat

서비스 절차

서비스 문의

이름

이메일 주소

소속

연락처

제목

내용- 화합물개수

내용-타깃개수

내용-농도개수

내용-기타 문의사항에 대해 자유롭게 기술해주세요.

개인정보 취급 방침 동의 개인정보 취급 방침 동의 동의합니다.

Metabolic and Cardiovascular In Vivo Models

| Pharmacology Discovery Services (Eurofins Discovery Partner Lab) 공식 대리점

INTRODUCTION

Eurofins Discovery의 Pharmacology Discovery Services는 30년 이상의 in vivo testing 경험을 바탕으로 Metabolic/Endocrine disease에 대한 후보약물의 Efficacy 및 side-effect profiling 연구를 위한 in vivo model을 제공합니다.

High-quality, Reproducible data
Dose-dependent manner
Approved benchmark positive control
Custom Model Development

Metabolic Disease Models include:

Type I (induction by streptotozocin) diabetes models: Insulin-independent pathways 관찰
Type II diabetes models: Wildtype or genetic variants (db/db, ob/ob or ZDF) model, 식이 조절을 통해 약물이 glucose metabolism과 비만에 미치는 영향 관찰
Chronic kidney disease models
Acute and chronic hepatic injury

MODEL LIST

Cardiovascular In vivo Models
Model Name	Item Number	Species
Bleeding Time	510000	Mouse
Bleeding Time	510200	Rat
Cardiovascular, Blood Pressure & Heart Rate (SHR 1, 2, 4 hr)	515000	Rat
Cardiovascular, Blood Pressure & Heart Rate (NTR, 0.5, 1, 2 hrs)	515310	Rat
Cardiovascular, QTc Interval	516350	Guinea Pig
Clotting Time	522500	Rat
Thrombosis, Abdominal Aorta, Ferric Chloride-Induced	578400	Rat
Thrombosis, Vena Cava, Thromboplastin-Induced	578570	Rat

Metabolic In vivo Models
Model Name	Item Number	Species
Cholesterol, Normal Serum (Total, HDL, LDL, TG)	518000	Mouse
Cholesterol, Serum (Total, HDL, LDL, TG) Diet-Induced	518030	Guinea Pig
Cholesterol, Serum (Total, HDL, LDL, TG) Diet-Induced	518050	Hamster
Diabetes, Type I, Streptozotocin-Induced	541000	Mouse
Diabetes, Type I, Streptozotocin-Induced	541010	Rat
Diabetes, Type II, db/db Mouse	541630	Mouse
Diabetes, Type II, KK-AY Mouse	541620	Mouse
Diabetes, Type II, Obese Zucker Diabetic Fatty (ZDF) Rats	541700	Rat
Glucose, Blood, Oral Glucose Tolerance Test (OGTT)	540100	Mouse
Glucose, Blood, Oral Glucose Tolerance Test (OGTT)	540110	Rat
Glucose, Serum, Fasted	539000	Mouse
Glucose, Serum, Starch-Loaded	541500	Mouse
Hematopoiesis, Anemia, Carboplatin-Induced	547300	Mouse
Hepatic Injury, Acetaminophen (APAP)-Induced	546040	Mouse
Hepatic Injury, Concanavalin A (Con-A)-Induced	546030	Mouse
Hepatic Injury, Liver Fibrosis, Chronic, Carbon Tetrachloride (CCl4)-Induced	546060	Rat
Hepatic Injury, Liver Fibrosis, Chronic, Carbon Tetrachloride (CCI4) with Phenobarbial-Induced	546050	Rat
Hepatic Injury, Nonalcoholic Steatohepatitis (NASH), MCD Diet-Induced	546080	Mouse
Obesity, Diet-Induced	518510	Mouse
Pancreatitis, Acute, Caerulein-Induced	566000	Mouse
Pancreatitis, Chronic, Caerulein-Induced	566100	Mouse
Wound Healing, Skin	595000	Mouse
Wound Healing, Skin, db/db Mouse	595020	Mouse

서비스 절차

서비스 문의

이름

이메일 주소

소속

연락처

제목

내용- 화합물개수

내용-타깃개수

내용-농도개수

내용-기타 문의사항에 대해 자유롭게 기술해주세요.

개인정보 취급 방침 동의 개인정보 취급 방침 동의 동의합니다.

« Older Entries