Metabolic and Cardiovascular In Vivo Models
| Pharmacology Discovery Services (Eurofins Discovery Partner Lab) 공식 대리점
INTRODUCTION
Eurofins Discovery의 Pharmacology Discovery Services는 30년 이상의 in vivo testing 경험을 바탕으로 Metabolic/Endocrine disease에 대한 후보약물의 Efficacy 및 side-effect profiling 연구를 위한 in vivo model을 제공합니다.
- High-quality, Reproducible data
- Dose-dependent manner
- Approved benchmark positive control
- Custom Model Development
Metabolic Disease Models include:
- Type I (induction by streptotozocin) diabetes models: Insulin-independent pathways 관찰
- Type II diabetes models: Wildtype or genetic variants (db/db, ob/ob or ZDF) model, 식이 조절을 통해 약물이 glucose metabolism과 비만에 미치는 영향 관찰
- Chronic kidney disease models
- Acute and chronic hepatic injury
MODEL LIST
| Cardiovascular In vivo Models | ||
| Model Name | Item Number | Species |
| Bleeding Time | 510000 | Mouse |
| Bleeding Time | 510200 | Rat |
| Cardiovascular, Blood Pressure & Heart Rate (SHR 1, 2, 4 hr) | 515000 | Rat |
| Cardiovascular, Blood Pressure & Heart Rate (NTR, 0.5, 1, 2 hrs) | 515310 | Rat |
| Cardiovascular, QTc Interval | 516350 | Guinea Pig |
| Clotting Time | 522500 | Rat |
| Thrombosis, Abdominal Aorta, Ferric Chloride-Induced | 578400 | Rat |
| Thrombosis, Vena Cava, Thromboplastin-Induced | 578570 | Rat |
| Metabolic In vivo Models | ||
| Model Name | Item Number | Species |
| Cholesterol, Normal Serum (Total, HDL, LDL, TG) | 518000 | Mouse |
| Cholesterol, Serum (Total, HDL, LDL, TG) Diet-Induced | 518030 | Guinea Pig |
| Cholesterol, Serum (Total, HDL, LDL, TG) Diet-Induced | 518050 | Hamster |
| Diabetes, Type I, Streptozotocin-Induced | 541000 | Mouse |
| Diabetes, Type I, Streptozotocin-Induced | 541010 | Rat |
| Diabetes, Type II, db/db Mouse | 541630 | Mouse |
| Diabetes, Type II, KK-AY Mouse | 541620 | Mouse |
| Diabetes, Type II, Obese Zucker Diabetic Fatty (ZDF) Rats | 541700 | Rat |
| Glucose, Blood, Oral Glucose Tolerance Test (OGTT) | 540100 | Mouse |
| Glucose, Blood, Oral Glucose Tolerance Test (OGTT) | 540110 | Rat |
| Glucose, Serum, Fasted | 539000 | Mouse |
| Glucose, Serum, Starch-Loaded | 541500 | Mouse |
| Hematopoiesis, Anemia, Carboplatin-Induced | 547300 | Mouse |
| Hepatic Injury, Acetaminophen (APAP)-Induced | 546040 | Mouse |
| Hepatic Injury, Concanavalin A (Con-A)-Induced | 546030 | Mouse |
| Hepatic Injury, Liver Fibrosis, Chronic, Carbon Tetrachloride (CCl4)-Induced | 546060 | Rat |
| Hepatic Injury, Liver Fibrosis, Chronic, Carbon Tetrachloride (CCI4) with Phenobarbial-Induced | 546050 | Rat |
| Hepatic Injury, Nonalcoholic Steatohepatitis (NASH), MCD Diet-Induced | 546080 | Mouse |
| Obesity, Diet-Induced | 518510 | Mouse |
| Pancreatitis, Acute, Caerulein-Induced | 566000 | Mouse |
| Pancreatitis, Chronic, Caerulein-Induced | 566100 | Mouse |
| Wound Healing, Skin | 595000 | Mouse |
| Wound Healing, Skin, db/db Mouse | 595020 | Mouse |
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