ADULT HUMAN DRG & SPINAL CORD
AnaBios는 Drug Discovery의 모든 단계에 Human Tissue Sample 및 Service를 제공합니다.
ADULT HUMAN DRG & SPINAL CORD
Physiologically Functional Tissue for Drug Discovery
– AnaBios는 기증에 동의한 성인들로부터 윤리적으로 공급받은 high-quality adult human tissue를 제공합니다.
– Diseased 또는 normal tissue 모두 제공 가능하며 성별, 나이, 인종, BMI를 포함한 인구통계학적 정보를 제공합니다.
| Human Tissue | Diseased | Tissue Types | Uses |
| Spinal Cord | Please inquire | Tissue sections | Genomic sequencing (tissue) RNAscope, proteomics, IHC |
DRG Application
Pain, Itch, CNS research
Spinal Cord Application
PROTEOMICS, GENOMIC SEQUENCING, RNASCOPE, IHC
| Item | Cat # | Cat # |
| Dorsal Root Ganglion | Spinal Cord | |
| T1 | DRG-101/F | HSC-101/F |
| T2 | DRG-102/F | HSC-102/F |
| T3 | DRG-103/F | HSC-103/F |
| T4 | DRG-104/F | HSC-104/F |
| T5 | DRG-105/F | HSC-105/F |
| T6 | DRG-106/F | HSC-106/F |
| T7 | DRG-107/F | HSC-107/F |
| T8 | DRG-108/F | HSC-108/F |
| T9 | DRG-109/F | HSC-109/F |
| T10 | DRG-110/F | HSC-110/F |
| T11 | DRG-111/F | HSC-111/F |
| T12 | DRG-112/F | HSC-112/F |
| L1 | DRG-113/F | HSC-113/F |
| L2 | DRG-114F | HSC-114/F |
| L3 | DRG-115/F | HSC-115/F |
| L4 | DRG-1116/F | HSC-116/F |
| L5 | DRG-117F | HSC-117/F |
| S1 | DRG-118/F | HSC-118/F |
| S2 | – | HSC-119/F |
| S3 | – | HSC-120/F |
| S4 | – | HSC-121/F |
| S5 | – | HSC-122/F |
[Normal Spinal Cord Donors]
| Item | Cat # |
| NORMAL | SCN-600/F |
VALIDATION OF HUMAN DRG NEURONS
► Membrane voltage traces from Isolated human DRG neurons patch clamped in current clamp mode.
TRPA1 agonist (AITC) activated spontaneous action potential (AP) firing in a high fraction of DRG neurons (4/5, upper trace); and the pruritogen, histamine activated AP firing in 50% of DRG neurons (6/12, middle trace). The bottom trace shows the impact of inflammatory mediators, PGE2 and bradykinin on AP discharge In DRG neurons from healthy individuals never exhibit secondarily evoked AP’s in response to current stimulation, while a subset of DRG neurons exposed to 5 minutes of PGE2/BK show continued firing in the presence of these molecules.
제품 & 서비스 문의